Paracrine Effects of Adipose-Derived Stem Cells on Matrix Stiffness-Induced Cardiac Myofibroblast Differentiation via Angiotensin II Type 1 Receptor and Smad7

• Main Authors: Yong, K.W., Li, Y., Liu, F., Gao, B., Lu, T.J., Wan Abas, Wan Abu Bakar, Wan Kamarul Zaman, Wan Safwani, Pingguan-Murphy, Belinda, Ma, Y., Xu, F., Huang, G.
• Format: Article
• Published: Nature Publishing Group 2016
• Subjects: R Medicine (General); TA Engineering (General). Civil engineering (General)
• Online Access: http://eprints.um.edu.my/18762/; http://dx.doi.org/10.1038/srep33067

Human mesenchymal stem cells (hMSCs) hold great promise in cardiac fibrosis therapy, due to their potential ability of inhibiting cardiac myofibroblast differentiation (a hallmark of cardiac fibrosis). However, the mechanism involved in their effects remains elusive. To explore this, it is necessary...