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Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells

Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a m...

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Main Authors: Lau, W.K., Goh, B.H., Kadir, H.A., Shu-Chien, A.C., Muhammad, T.S.T.
Format: Article
Published: 2015
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/16383/
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spelling my.um.eprints.163832016-09-08T02:42:06Z http://eprints.um.edu.my/16383/ Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells Lau, W.K. Goh, B.H. Kadir, H.A. Shu-Chien, A.C. Muhammad, T.S.T. Q Science (General) QD Chemistry Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPAR ligand activity. They were corresponded to PPAR-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPAR. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter. 2015 Article PeerReviewed Lau, W.K. and Goh, B.H. and Kadir, H.A. and Shu-Chien, A.C. and Muhammad, T.S.T. (2015) Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells. Molecules, 20 (12). pp. 22301-22314. ISSN 1420-3049 DOI: 10.3390/molecules201219847
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Lau, W.K.
Goh, B.H.
Kadir, H.A.
Shu-Chien, A.C.
Muhammad, T.S.T.
Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells
description Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPAR ligand activity. They were corresponded to PPAR-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPAR. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter.
format Article
author Lau, W.K.
Goh, B.H.
Kadir, H.A.
Shu-Chien, A.C.
Muhammad, T.S.T.
author_facet Lau, W.K.
Goh, B.H.
Kadir, H.A.
Shu-Chien, A.C.
Muhammad, T.S.T.
author_sort Lau, W.K.
title Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells
title_short Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells
title_full Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells
title_fullStr Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells
title_full_unstemmed Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells
title_sort potent ppar gamma ligands from swietenia macrophylla are capable of stimulating glucose uptake in muscle cells
publishDate 2015
url http://eprints.um.edu.my/16383/
_version_ 1643690265101205504
score 13.159267

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