Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework

• Main Authors: Sun, R.W.Y., Zhang, M., Li, D., Zhang, Z.F., Cai, H., Li, M., Xian, Y.J., Ng, S.W., Wong, A.S.T.
• Format: Article
• Published: 2015
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/16191/

A dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin-resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug-release testing, in this study, a set of transwell assay-based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn-MOF towards A2780cis.