Ethnicity and drug therapy for hypertension
Physiological and pharmacological responses may be influenced by ethnicity as a result of genetic factors, environmental factors and/or their interaction. This review is divided into 2 parts. Firstly, there will be overview of ethnicity as a determinant of drug metabolism and response with reference...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Article |
Published: |
Bentham Science Publishers
2003
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/1578/ http://www.ncbi.nlm.nih.gov/pubmed/12871202 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.um.eprints.1578 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.15782019-02-11T09:08:03Z http://eprints.um.edu.my/1578/ Ethnicity and drug therapy for hypertension Amudha, K. Wong, L.P. Choy, Anna-Maria J. Lang, Chim C. R Medicine Physiological and pharmacological responses may be influenced by ethnicity as a result of genetic factors, environmental factors and/or their interaction. This review is divided into 2 parts. Firstly, there will be overview of ethnicity as a determinant of drug metabolism and response with reference to antihypertensive agents. The concept of ethnicity has been applied extensively to the study of hypertension especially in American blacks in whom the hypertension is more common and more aggressive. Thus, the second part of this review will then focus on examining the black-white differences in physiological responses to pharmacological challenge that may provide a link between these models and known ethnic differences in drug responses. We will discuss the hypertension studies that have examined the relative effectiveness of different classes of antihypertensive agents including several recent cardiovascular outcome trials that either have a high proportion of blacks or were conducted entirely in black subjects. Bentham Science Publishers 2003 Article PeerReviewed Amudha, K. and Wong, L.P. and Choy, Anna-Maria J. and Lang, Chim C. (2003) Ethnicity and drug therapy for hypertension. Current Pharmaceutical Design, 9 (21). pp. 1691-701. ISSN 1381-6128 http://www.ncbi.nlm.nih.gov/pubmed/12871202 12871202 |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
topic |
R Medicine |
spellingShingle |
R Medicine Amudha, K. Wong, L.P. Choy, Anna-Maria J. Lang, Chim C. Ethnicity and drug therapy for hypertension |
description |
Physiological and pharmacological responses may be influenced by ethnicity as a result of genetic factors, environmental factors and/or their interaction. This review is divided into 2 parts. Firstly, there will be overview of ethnicity as a determinant of drug metabolism and response with reference to antihypertensive agents. The concept of ethnicity has been applied extensively to the study of hypertension especially in American blacks in whom the hypertension is more common and more aggressive. Thus, the second part of this review will then focus on examining the black-white differences in physiological responses to pharmacological challenge that may provide a link between these models and known ethnic differences in drug responses. We will discuss the hypertension studies that have examined the relative effectiveness of different classes of antihypertensive agents including several recent cardiovascular outcome trials that either have a high proportion of blacks or were conducted entirely in black subjects. |
format |
Article |
author |
Amudha, K. Wong, L.P. Choy, Anna-Maria J. Lang, Chim C. |
author_facet |
Amudha, K. Wong, L.P. Choy, Anna-Maria J. Lang, Chim C. |
author_sort |
Amudha, K. |
title |
Ethnicity and drug therapy for hypertension |
title_short |
Ethnicity and drug therapy for hypertension |
title_full |
Ethnicity and drug therapy for hypertension |
title_fullStr |
Ethnicity and drug therapy for hypertension |
title_full_unstemmed |
Ethnicity and drug therapy for hypertension |
title_sort |
ethnicity and drug therapy for hypertension |
publisher |
Bentham Science Publishers |
publishDate |
2003 |
url |
http://eprints.um.edu.my/1578/ http://www.ncbi.nlm.nih.gov/pubmed/12871202 |
_version_ |
1643686742087172096 |
score |
13.222552 |