Criofolinine and vernavosine, new pentacyclic indole alkaloids incorporating pyrroloazepine and pyridopyrimidine moieties derived from a common yohimbine precursor

• Main Authors: Nge, C.E., Gan, C.Y., Lim, K.H., Ting, KN., Low, Y.Y., Kam, T.S.
• Format: Article
• Published: American Chemical Society 2014
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/15390/

Two new indole alkaloids characterized by previously unencountered natural product skeletons, viz., criofolinine (1), incorporating a pyrroloazepine motif within a pentacyclic ring system, and vernavosine (2, isolated as its ethyl ether derivative 3, which on hydrolysis regenerated the putative prec...