Pictet-Spengler reaction-based biosynthetic machinery in fungi

• Main Authors: Yan, W., Ge, H.M., Wang, G., Jiang, N., Mei, Y.N., Jiang, R., Li, S.J., Chen, C.J., Jiao, R.H., Xu, Q., Ng, Seik Weng, Tan, R.X.
• Format: Article
• Published: National Academy of Sciences 2014
• Subjects: Q Science (General)
• Online Access: http://eprints.um.edu.my/15385/

The Pictet-Spengler (PS) reaction constructs plant alkaloids such as morphine and camptothecin, but it has not yet been noticed in the fungal kingdom. Here, a silent fungal Pictet-Spenglerase (FPS) gene of Chaetomium globosum 1C51 residing in Epinephelus drummondhayi guts is described and ascertaine...