Changing prognosis of childhood cancer--an overview.

Significant advances in diagnosis and management have cured the majority of children with cancer. In the leukaemias, the commonest childhood malignancy, intensive induction-consolidation is important to ensure a lasting cure in about 65-80% and to eliminate the traditionally bad prognostic risk fact...

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Main Author: Lin, H.P.
Format: Article
Published: 1993
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Online Access:http://eprints.um.edu.my/1423/
http://www.ncbi.nlm.nih.gov/pubmed/8363329
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spelling my.um.eprints.14232014-10-21T01:10:02Z http://eprints.um.edu.my/1423/ Changing prognosis of childhood cancer--an overview. Lin, H.P. RJ Pediatrics Significant advances in diagnosis and management have cured the majority of children with cancer. In the leukaemias, the commonest childhood malignancy, intensive induction-consolidation is important to ensure a lasting cure in about 65-80% and to eliminate the traditionally bad prognostic risk factors associated with less intensive treatment. Bone marrow transplantation (BMT) has a curative role in the minority who relapse particularly while on treatment. With few exceptions, most paediatric solid tumours are curable. Although the multimodal approach is responsible for the progress made, chemotherapy has emerged to play a dominant role. It has, in several tumours, obviated or reduced the need for radiotherapy and/or surgery. In Wilms' tumour and Hodgkin's disease, refinement of treatment is now in progress to reduce therapy-related morbidity while not sacrificing efficacy. 1993-03 Article PeerReviewed Lin, H.P. (1993) Changing prognosis of childhood cancer--an overview. Annals of the Academy of Medicine, Singapore, 22 (2). pp. 182-6. ISSN 0304-4602 http://www.ncbi.nlm.nih.gov/pubmed/8363329 8363329
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RJ Pediatrics
spellingShingle RJ Pediatrics
Lin, H.P.
Changing prognosis of childhood cancer--an overview.
description Significant advances in diagnosis and management have cured the majority of children with cancer. In the leukaemias, the commonest childhood malignancy, intensive induction-consolidation is important to ensure a lasting cure in about 65-80% and to eliminate the traditionally bad prognostic risk factors associated with less intensive treatment. Bone marrow transplantation (BMT) has a curative role in the minority who relapse particularly while on treatment. With few exceptions, most paediatric solid tumours are curable. Although the multimodal approach is responsible for the progress made, chemotherapy has emerged to play a dominant role. It has, in several tumours, obviated or reduced the need for radiotherapy and/or surgery. In Wilms' tumour and Hodgkin's disease, refinement of treatment is now in progress to reduce therapy-related morbidity while not sacrificing efficacy.
format Article
author Lin, H.P.
author_facet Lin, H.P.
author_sort Lin, H.P.
title Changing prognosis of childhood cancer--an overview.
title_short Changing prognosis of childhood cancer--an overview.
title_full Changing prognosis of childhood cancer--an overview.
title_fullStr Changing prognosis of childhood cancer--an overview.
title_full_unstemmed Changing prognosis of childhood cancer--an overview.
title_sort changing prognosis of childhood cancer--an overview.
publishDate 1993
url http://eprints.um.edu.my/1423/
http://www.ncbi.nlm.nih.gov/pubmed/8363329
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