Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3

• Main Authors: Argiropoulos, B., Yung, E., Xiang, P., Lo, C.Y., Kuchenbauer, F., Palmqvist, L., Reindl, C., Heuser, M., Sekulovic, S., Rosten, P., Muranyi, A., Goh, Siew-Lee, Featherstone, M., Humphries, R.K.
• Format: Article
• Published: 2010
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/14215/

MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is ratelimiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformat...