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Development of potential antiviral strategy against coxsackievirus B4

Coxsackievirus B4 (CVB4) can cause a broad range of diseases such as aseptic meningitis, meningoencephalitis, myocarditis, hepatitis, pancreatitis, gastroenteritis, necrotizing enterocolitis, pneumonia and sudden death in the neonates. CVB4 has also been implicated as a possible etiological agent fo...

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Main Authors: Tan, E.L., Wong, A.P.Y., Poh, C.L.
Format: Article
Published: Elsevier 2010
Subjects:
Q Science (General)
Online Access:http://eprints.um.edu.my/14188/
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spelling my.um.eprints.141882015-10-06T06:49:40Z http://eprints.um.edu.my/14188/ Development of potential antiviral strategy against coxsackievirus B4 Tan, E.L. Wong, A.P.Y. Poh, C.L. Q Science (General) Coxsackievirus B4 (CVB4) can cause a broad range of diseases such as aseptic meningitis, meningoencephalitis, myocarditis, hepatitis, pancreatitis, gastroenteritis, necrotizing enterocolitis, pneumonia and sudden death in the neonates. CVB4 has also been implicated as a possible etiological agent for type 1 insulin dependent diabetes mellitus (IDDM). In this study, the possibility of RNA interference (RNAi) as a potential therapeutic approach to treat CVB4 infection was explored. The results showed that the Rhabdomyosarcoma (RD) cells treated with 19-mer siRNAs displayed high specificity against CVB4 replication without displaying any sign of target effects. The siRNA targeting the 3C(Pro) region of CVB4 genome was also established to be the most effective in inhibition of CVB4 replication in RD cell line in a dosage dependent manner, indicating its potential to be developed as an antiviral strategy against CVB4. (C) 2010 Elsevier B.V. All rights reserved. Elsevier 2010 Article PeerReviewed Tan, E.L. and Wong, A.P.Y. and Poh, C.L. (2010) Development of potential antiviral strategy against coxsackievirus B4. Virus Research, 150 (1-2). pp. 85-92.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
spellingShingle Q Science (General)
Tan, E.L.
Wong, A.P.Y.
Poh, C.L.
Development of potential antiviral strategy against coxsackievirus B4
description Coxsackievirus B4 (CVB4) can cause a broad range of diseases such as aseptic meningitis, meningoencephalitis, myocarditis, hepatitis, pancreatitis, gastroenteritis, necrotizing enterocolitis, pneumonia and sudden death in the neonates. CVB4 has also been implicated as a possible etiological agent for type 1 insulin dependent diabetes mellitus (IDDM). In this study, the possibility of RNA interference (RNAi) as a potential therapeutic approach to treat CVB4 infection was explored. The results showed that the Rhabdomyosarcoma (RD) cells treated with 19-mer siRNAs displayed high specificity against CVB4 replication without displaying any sign of target effects. The siRNA targeting the 3C(Pro) region of CVB4 genome was also established to be the most effective in inhibition of CVB4 replication in RD cell line in a dosage dependent manner, indicating its potential to be developed as an antiviral strategy against CVB4. (C) 2010 Elsevier B.V. All rights reserved.
format Article
author Tan, E.L.
Wong, A.P.Y.
Poh, C.L.
author_facet Tan, E.L.
Wong, A.P.Y.
Poh, C.L.
author_sort Tan, E.L.
title Development of potential antiviral strategy against coxsackievirus B4
title_short Development of potential antiviral strategy against coxsackievirus B4
title_full Development of potential antiviral strategy against coxsackievirus B4
title_fullStr Development of potential antiviral strategy against coxsackievirus B4
title_full_unstemmed Development of potential antiviral strategy against coxsackievirus B4
title_sort development of potential antiviral strategy against coxsackievirus b4
publisher Elsevier
publishDate 2010
url http://eprints.um.edu.my/14188/
_version_ 1643689749514289152
score 13.19449

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