Controlled release of C-type natriuretic peptide by microencapsulation dampens proinflammatory effects induced by IL-1 beta in cartilage explants

• Main Authors: Peake, N.J., Pavlov, A.M., D'Souza, A., Pingguan-Murphy, Belinda, Sukhorukov, G.B., Hobbs, A.J., Chowdhury, T.T.
• Format: Article
• Published: 2015
• Subjects: T Technology (General); TA Engineering (General). Civil engineering (General)
• Online Access: http://eprints.um.edu.my/14050/; http://pubs.acs.org/doi/abs/10.1021/bm501575w

C-type natriuretic peptide (CNP) exhibits potent anti-inflammatory effects in chondrocytes that have the potential to repair cartilage damage observed in osteoarthritis (OA). However, treatments for OA have been challenging due to poor targeting and delivery of therapeutics. The present study fabric...