In situ normoxia enhances survival and proliferation rate of human adipose tissue-derived stromal cells without increasing the risk of tumourigenesis

• Main Authors: Choi, J.R., Pingguan-Murphy, Belinda, Wan Abas, Wan Abu Bakar, Yong, K.W., Poon, C.T., Noor Azmi, Mat Adenan, Omar, Siti Zawiah, Chua, K.H., Xu, F., Wan Kamarul Zaman, Wan Safwani
• Format: Article
• Published: Public Library of Science 2015
• Subjects: T Technology (General); TA Engineering (General). Civil engineering (General)
• Online Access: http://eprints.um.edu.my/14049/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304807/

Adipose tissue-derived stromal cells (ASCs) natively reside in a relatively low-oxygen tension (i.e., hypoxic) microenvironment in human body. Low oxygen tension (i.e., in situ normoxia), has been known to enhance the growth and survival rate of ASCs, which, however, may lead to the risk of tumourig...