Pulmonary toxicity of instilled silver nanoparticles: Influence of size, coating and rat strain

• Main Authors: Seiffert, J., Hussain, F., Wiegman, C., Li, F., Bey, L., Baker, W., Porter, A., Ryan, M.P., Chang, Y., Gow, A., Zhang, J.F., Zhu, J., Tetley, T.D., Chung, K.F.
• Format: Article
• Language: English
• Published: Public Library of Science 2015
• Subjects: T Technology (General); TJ Mechanical engineering and machinery
• Online Access: http://eprints.um.edu.my/13797/1/Pulmonary_Toxicity_of_Instilled_Silver_Nanoparticles.pdf; http://eprints.um.edu.my/13797/; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119726

Particle size and surface chemistry are potential determinants of silver nanoparticle (AgNP) respiratory toxicity that may also depend on the lung inflammatory state. We compared the effects of intratracheally-administered AgNPs (20nm and 110nm; polyvinylpyrrolidone (PVP) and citrate-capped; 0.1 mg/...