The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells

• Main Authors: Looi, C.Y., Sasahara, Y., Watanabe, Y., Satoh, M., Hakozaki, I., Uchiyama, M., Wong, W.F., Du, W., Uchiyama, T., Kumaki, S., Tsuchiya, S., Kure, S.
• Format: Article
• Published: Oxford University Press 2014
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/13041/; http://intimm.oxfordjournals.org/content/26/6/341.long; http://dx.doi.org/10.1093/intimm/dxt072

Mutations in the gene encoding the Wiskott–Aldrich syndrome protein (WASP) are responsible for Wiskott–Aldrich syndrome and WASP is a major actin regulator in the cytoplasm. Although rare gain-of-function mutations in the WASP gene are known to result in X-linked neutropenia (XLN), the molecular pat...