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Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxind...

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Main Authors: Ahmad, K., Thomas, N.F., Hadi, A.H.A., Mukhtar, M.R., Mohamad, K., Nafiah, M.A., Takeya, K., Morita, H., Litaudon, M., Arai, H., Awang, Khalijah
Format: Article
Published: Pharmaceutical Soc Japan 2010
Subjects:
Q Science (General)
Online Access:http://eprints.um.edu.my/12608/
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spelling my.um.eprints.126082019-03-01T09:01:12Z http://eprints.um.edu.my/12608/ Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia Ahmad, K. Thomas, N.F. Hadi, A.H.A. Mukhtar, M.R. Mohamad, K. Nafiah, M.A. Takeya, K. Morita, H. Litaudon, M. Arai, H. Awang, Khalijah Q Science (General) A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 21) NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta. Pharmaceutical Soc Japan 2010 Article PeerReviewed Ahmad, K. and Thomas, N.F. and Hadi, A.H.A. and Mukhtar, M.R. and Mohamad, K. and Nafiah, M.A. and Takeya, K. and Morita, H. and Litaudon, M. and Arai, H. and Awang, Khalijah (2010) Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia. Chemical & Pharmaceutical Bulletin, 58 (8). pp. 1085-1087.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
spellingShingle Q Science (General)
Ahmad, K.
Thomas, N.F.
Hadi, A.H.A.
Mukhtar, M.R.
Mohamad, K.
Nafiah, M.A.
Takeya, K.
Morita, H.
Litaudon, M.
Arai, H.
Awang, Khalijah
Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia
description A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 21) NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.
format Article
author Ahmad, K.
Thomas, N.F.
Hadi, A.H.A.
Mukhtar, M.R.
Mohamad, K.
Nafiah, M.A.
Takeya, K.
Morita, H.
Litaudon, M.
Arai, H.
Awang, Khalijah
author_facet Ahmad, K.
Thomas, N.F.
Hadi, A.H.A.
Mukhtar, M.R.
Mohamad, K.
Nafiah, M.A.
Takeya, K.
Morita, H.
Litaudon, M.
Arai, H.
Awang, Khalijah
author_sort Ahmad, K.
title Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia
title_short Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia
title_full Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia
title_fullStr Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia
title_full_unstemmed Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia
title_sort oppositinines a and b: new vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia
publisher Pharmaceutical Soc Japan
publishDate 2010
url http://eprints.um.edu.my/12608/
_version_ 1643689336894390272
score 13.214268

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