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Iron regulated outer membrane proteins (IROMPs) as potential targets against carbapenem-resistant Acinetobacter spp. isolated from a Medical Centre in Malaysia

In this study, a 29-kDa OMP has been identified to be the major outer membrane protein in A. baumannii / calcoaceticus and loss of this porin and overexpression of IROMPs have contributed to carbapenem resistance. Polyclonal antibodies raised against IROMPs may have a role in antimicrobial therapy i...

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Bibliographic Details
Main Authors: Hwa, W.E., Subramaniam, G., Mansor, Marzida, Yan, O.S., Anbazhagan, D., Devi, S.S.
Format: Article
Published: Medknow Publications 2010
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/1231/
http://www.ijmr.org.in/temp/IndianJMedRes1314578-1565723_042057.pdf
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Summary:In this study, a 29-kDa OMP has been identified to be the major outer membrane protein in A. baumannii / calcoaceticus and loss of this porin and overexpression of IROMPs have contributed to carbapenem resistance. Polyclonal antibodies raised against IROMPs may have a role in antimicrobial therapy in these isolates.

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