Population pharmacokinetics of vancomycin in premature Malaysian neonates: identification of predictors for dosing determination

• Main Authors: Lo, Y., van Hasselt, J.G.C., Heng, S., Lim, C., Lee, T., Charles, B.G.
• Format: Article
• Published: American Society for Microbiology 2010
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/1226/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876370/

The present study determined the pharmacokinetic profile of vancomycin in premature Malaysian infants. A one-compartment infusion model with first-order elimination was fitted to serum vancomycin concentration data (n = 835 points) obtained retrospectively from the drug monitoring records of 116 pre...