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The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.

Seed of Mucuna pruriens (Velvet beans) has been prescribed by traditional medicine practitioners in Nigeria as a prophylactic oral antisnake remedy. In the present studies, we investigated the protective effects of M. pruriens seed extract (MPE) against histopathological changes induced by intraveno...

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Main Authors: Fung, S.Y., Tan, N.H., Liew, S.H., Sim, S.M., Aguiyi, J.C.
Format: Article
Published: Malaysian Society of Parasitology and Tropical Medicine 2009
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/1137/
http://www.ncbi.nlm.nih.gov/pubmed/19696731
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spelling my.um.eprints.11372017-10-06T02:56:47Z http://eprints.um.edu.my/1137/ The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats. Fung, S.Y. Tan, N.H. Liew, S.H. Sim, S.M. Aguiyi, J.C. R Medicine Seed of Mucuna pruriens (Velvet beans) has been prescribed by traditional medicine practitioners in Nigeria as a prophylactic oral antisnake remedy. In the present studies, we investigated the protective effects of M. pruriens seed extract (MPE) against histopathological changes induced by intravenous injection of Naja sputatrix (Malayan cobra) venom in rats pretreated with the seed extract. Examination by light microscope revealed that the venom induced histopathological changes in heart and blood vessels in liver, but no effect on brain, lung, kidney and spleen. The induced changes were prevented by pretreatment of the rats with MPE. Our results suggest that MPE pretreatment protects rat heart and liver blood vessels against cobra venom-induced damages. Malaysian Society of Parasitology and Tropical Medicine 2009-04 Article PeerReviewed Fung, S.Y. and Tan, N.H. and Liew, S.H. and Sim, S.M. and Aguiyi, J.C. (2009) The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats. Tropical Biomedicine, 26 (1). pp. 80-4. ISSN 0127-5720 http://www.ncbi.nlm.nih.gov/pubmed/19696731 19696731
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Fung, S.Y.
Tan, N.H.
Liew, S.H.
Sim, S.M.
Aguiyi, J.C.
The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.
description Seed of Mucuna pruriens (Velvet beans) has been prescribed by traditional medicine practitioners in Nigeria as a prophylactic oral antisnake remedy. In the present studies, we investigated the protective effects of M. pruriens seed extract (MPE) against histopathological changes induced by intravenous injection of Naja sputatrix (Malayan cobra) venom in rats pretreated with the seed extract. Examination by light microscope revealed that the venom induced histopathological changes in heart and blood vessels in liver, but no effect on brain, lung, kidney and spleen. The induced changes were prevented by pretreatment of the rats with MPE. Our results suggest that MPE pretreatment protects rat heart and liver blood vessels against cobra venom-induced damages.
format Article
author Fung, S.Y.
Tan, N.H.
Liew, S.H.
Sim, S.M.
Aguiyi, J.C.
author_facet Fung, S.Y.
Tan, N.H.
Liew, S.H.
Sim, S.M.
Aguiyi, J.C.
author_sort Fung, S.Y.
title The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.
title_short The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.
title_full The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.
title_fullStr The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.
title_full_unstemmed The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.
title_sort protective effects of mucuna pruriens seed extract against histopathological changes induced by malayan cobra (naja sputatrix) venom in rats.
publisher Malaysian Society of Parasitology and Tropical Medicine
publishDate 2009
url http://eprints.um.edu.my/1137/
http://www.ncbi.nlm.nih.gov/pubmed/19696731
_version_ 1643686680888082432
score 13.160551

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