Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma
The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subj...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Society for General Microbiology
2014
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/11367/1/Epstein%E2%80%93Barr_virus%2C_the_germinal_centre_and_the_development_of_Hodgkin%E2%80%99s_lymphoma.pdf http://eprints.um.edu.my/11367/ http://www.ncbi.nlm.nih.gov/pubmed/24893782 |
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| Summary: | The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis.
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