MicroRNA pathways: An emerging role in identification of therapeutic strategies
For years researchers have exerted every effort to improve the influential roles of microRNA (miRNA) in regulating genes that direct mammalian cell development and function. In spite of numerous advancements, many facets of miRNA generation remain unresolved due to the perplexing regulatory ne...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/11366/1/MicroRNA_pathways_an_emerging_role_in_identification_of_therapeutic_strategies.pdf http://eprints.um.edu.my/11366/ |
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| Summary: | For years researchers have exerted every effort to improve the influential roles of microRNA
(miRNA) in regulating genes that direct mammalian cell development and function. In spite of
numerous advancements, many facets of miRNA generation remain unresolved due to the
perplexing regulatory networks. The biogenesis of miRNA, eminently endures as a mystery as no
universal pathway defines or explicates the variegation in the rise of miRNAs. Early evidence in
biogenesis ignited specific steps of being omitted or replaced that eventuate in the individual
miRNAs of different mechanisms. Understanding the basic foundation concerning how miRNAs are
generated and function will help with diagnostic tools and therapeutic strategies. This review
encompasses the canonical and the non-canonical pathways involved in miRNA biogenesis, while
elucidating how miRNAs regulate genes at the nuclear level and also the mechanism that lies behind circulating miRNAs. |
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