The fetal sex ratio and metabolic, biochemical, haematological and clinical indicators of severity of hyperemesis gravidarum

• Main Authors: Tan, P.C., Jacob, R., Quek, K.F., Omar, S.Z.
• Format: Article
• Published: Elsevier 2006
• Subjects: R Medicine; RG Gynecology and obstetrics
• Online Access: http://eprints.um.edu.my/10870/; http://onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2006.00947.x/full

The association between female fetal sex and hyperemesis gravidarum is well established in European and North American populations. The association between female fetuses and severity of hyperemesis remains uncertain. A retrospective study based on case notes review of 166 Asian women hospitalised for hyperemesis was performed. Female fetuses were significantly associated with hyperemesis in our population (P = 0.004, OR 1.6, 95 CI 1.2-2.2) as well as associated with severe ketonuria and high urea. When both severe ketonuria and high urea were present at initial hospital admission for hyperemesis, 83 (95 CI 66-93) of the fetuses were female.