Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors

• Main Authors: Beniddir, M.A.A., Le Borgne, E.A., Iorga, B.L.A., Loaëc, N.B.C., Lozach, O.B., Meijer, L.B.C., Awang, K.D., Litaudon, M.A.
• Format: Article
• Published: American Chemical Society 2014
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/10701/; http://www.scopus.com/inward/record.url?eid=2-s2.0-84901664872&partnerID=40&md5=4dca11a45560165c4a7f967402c60421

Two new acridone alkaloids, chlorospermines A and B (1 and 2), were isolated from the stem bark of Glycosmis chlorosperma, together with the known atalaphyllidine (3) and acrifoline (4), by means of bioguided isolation using an in vitro enzyme assay against DYRK1A. Acrifoline (4) and to a lesser ext...