The oxidative stress of hyperglycemia and the inflammatory process in endothelial cells.

• Main Authors: Muniandy, S., Qvist, R., Yan, G.O.S., Bee, C.J., Chu, Y.K., Rayappan, A.V.
• Format: Article
• Published: The University of Tokushima, Faculty of Medicine 2009
• Subjects: RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/1070/; https://doi.org/10.2152/jmi.56.6

Hyperglycemia and insulin resistance are common in many critically ill patients. Hyperglycemia increases the production of reactive oxygen species in cells, stimulates the production of the potent proinflammatory cytokines IL-8 and TNF-alpha, and enhances the expression of haem oxygenase-1, an induc...