Molecular characterization showed limited genetic diversity among Salmonella Enteritidis isolated from humans and animals in Malaysia
Salmonella enterica serovar Enteritidis (S. Enteritidis) is the most common causative agent of non-typhoidal salmonellosis in Malaysia. We aimed to characterize S. Enteritidis isolated from humans and animals by analyzing their antimicrobial resistance profiles and genotypes. A total of 111 strains...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10648/1/Ngoi%2C_2013.pdf_2.pdf http://eprints.um.edu.my/10648/ |
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| Summary: | Salmonella enterica serovar Enteritidis (S. Enteritidis) is the most common causative agent of non-typhoidal
salmonellosis in Malaysia. We aimed to characterize S. Enteritidis isolated from humans and animals by
analyzing their antimicrobial resistance profiles and genotypes. A total of 111 strains were characterized using
multiple-locus variable-number tandem repeat analysis, pulsed-field gel electrophoresis, and antimicrobial
susceptibility testing. Both typing methods revealed that genetically similar S.Enteritidis strains had persisted
among human and animal populations within the period of study (2003–2008). Only 39% of the strains were
multi-drug resistant (i.e., resistant to 3 or more classes of antimicrobial agents), with a majority (73%) of these
in low-risk phase (multiple antibiotic resistant index b0.20). Limited genetic diversity among clinical and
zoonotic S. Enteritidis suggested that animals are possible sources of human salmonellosis. The degree of
multi-drug resistance among the strains was generally low during the study period. |
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