Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff bases in rats
The current study described the synthesis and the in-vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds are characterized by elemental analysis, LC-MS, FTIR, 1H NMR, 13C NMR and UV-visible spectroscopy. In acute toxicity study, a single administration of the compounds was pe...
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my.um.eprints.105862019-01-30T01:25:40Z http://eprints.um.edu.my/10586/ Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff bases in rats Salga, M.S. Ali, Hapipah Mohd Abdulla, M.A. Abdelwahab, S.I. QD Chemistry The current study described the synthesis and the in-vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds are characterized by elemental analysis, LC-MS, FTIR, 1H NMR, 13C NMR and UV-visible spectroscopy. In acute toxicity study, a single administration of the compounds was performed orally to the rats at the single of 2000 mg/kg and then monitored for the possible side effects, mortality or behavioral changes up to 14 days. The serum level of AST, ALT, ALP, triglyceride, HDL, immunoglobulins (GAM) and the C-reactive proteins did not significantly change. The haematological indices WBC, HCT, RBC, MCV, MCHC, MCH is within the normal range. The renal function indices examined are within the reference range. Generally, the compounds exhibited low toxic effects that are required for further in-vivo therapeutic studies. MDPI 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10586/1/Acute_Oral_Toxicity_Evaluations_Of_Some_Zinc%28II%29_Complexes.pdf Salga, M.S. and Ali, Hapipah Mohd and Abdulla, M.A. and Abdelwahab, S.I. (2012) Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff bases in rats. International Journal of Molecular Sciences, 12. ISSN 1422-0067 |
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QD Chemistry Salga, M.S. Ali, Hapipah Mohd Abdulla, M.A. Abdelwahab, S.I. Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff bases in rats |
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The current study described the synthesis and the in-vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds are characterized by elemental
analysis, LC-MS, FTIR, 1H NMR, 13C NMR and UV-visible spectroscopy. In acute toxicity study, a single administration of the compounds was performed orally to the rats at the single of 2000 mg/kg and then monitored for the possible side effects, mortality or behavioral changes up to 14 days. The serum level of AST, ALT, ALP, triglyceride,
HDL, immunoglobulins (GAM) and the C-reactive proteins did not significantly change. The haematological indices WBC, HCT, RBC, MCV, MCHC, MCH is within the normal range. The renal function indices examined are within the reference range. Generally, the compounds exhibited low toxic effects that are required for further in-vivo therapeutic studies. |
format |
Article |
author |
Salga, M.S. Ali, Hapipah Mohd Abdulla, M.A. Abdelwahab, S.I. |
author_facet |
Salga, M.S. Ali, Hapipah Mohd Abdulla, M.A. Abdelwahab, S.I. |
author_sort |
Salga, M.S. |
title |
Acute oral toxicity evaluations of some Zinc(II) complexes
derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff bases
in rats |
title_short |
Acute oral toxicity evaluations of some Zinc(II) complexes
derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff bases
in rats |
title_full |
Acute oral toxicity evaluations of some Zinc(II) complexes
derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff bases
in rats |
title_fullStr |
Acute oral toxicity evaluations of some Zinc(II) complexes
derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff bases
in rats |
title_full_unstemmed |
Acute oral toxicity evaluations of some Zinc(II) complexes
derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff bases
in rats |
title_sort |
acute oral toxicity evaluations of some zinc(ii) complexes
derived from 1-(2-salicylaldiminoethyl)piperazine schiff bases
in rats |
publisher |
MDPI |
publishDate |
2012 |
url |
http://eprints.um.edu.my/10586/1/Acute_Oral_Toxicity_Evaluations_Of_Some_Zinc%28II%29_Complexes.pdf http://eprints.um.edu.my/10586/ |
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1643688838885801984 |
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13.18916 |