Gastroprotection studies of Schiff Base Zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats

Background: The study was carried out to assess the gastroprotective effect of the zinc (II) complex against ethanol-induced acute hemorrhagic lesions in rats. Methodology/Principal Finding: The animals received their respective pre-treatments dissolved in tween 20 (5% v/v), orally. Ethanol (95% v...

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Main Authors: Golbabapour, S., Gwaram, N.S., Hassandarvish, P., Hajrezaie, M., Kamalidehghan, B., Abdulla, M.A., Ali, H.M., Hadi, A.H.A., Majid, N.A.
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Language:English
Published: Public Library of Science 2013
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Online Access:http://eprints.um.edu.my/10581/1/Gastroprotection_Studies_of_Schiff_Base_Zinc_%28II%29.pdf
http://eprints.um.edu.my/10581/
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spelling my.um.eprints.105812019-01-30T01:40:53Z http://eprints.um.edu.my/10581/ Gastroprotection studies of Schiff Base Zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats Golbabapour, S. Gwaram, N.S. Hassandarvish, P. Hajrezaie, M. Kamalidehghan, B. Abdulla, M.A. Ali, H.M. Hadi, A.H.A. Majid, N.A. QD Chemistry Background: The study was carried out to assess the gastroprotective effect of the zinc (II) complex against ethanol-induced acute hemorrhagic lesions in rats. Methodology/Principal Finding: The animals received their respective pre-treatments dissolved in tween 20 (5% v/v), orally. Ethanol (95% v/v) was orally administrated to induce superficial hemorrhagic mucosal lesions. Omeprazole (5.79061025 M/kg) was used as a reference medicine. The pre-treatment with the zinc (II) complex (2.18161025 and 4.36261025 M/kg) protected the gastric mucosa similar to the reference control. They significantly increased the activity levels of nitric oxide, catalase, superoxide dismutase, glutathione and prostaglandin E2, and decreased the level of malondialdehyde. The histology assessments confirmed the protection through remarkable reduction of mucosal lesions and increased the production of gastric mucosa. Immunohistochemistry and western blot analysis indicated that the complex might induced Hsp70 up-regulation and Bax down-regulation. The complex moderately increased the gastroprotectiveness in fine fettle. The acute toxicity approved the non-toxic characteristic of the complex(<87.24161025 M/kg). Conclusion/Significance: The gastroprotective effect of the zinc (II) complex was mainly through its antioxidant activity, enzymatic stimulation of prostaglandins E2, and up-regulation of Hsp70. The gastric wall mucus was also a remarkable protective mechanism. Public Library of Science 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10581/1/Gastroprotection_Studies_of_Schiff_Base_Zinc_%28II%29.pdf Golbabapour, S. and Gwaram, N.S. and Hassandarvish, P. and Hajrezaie, M. and Kamalidehghan, B. and Abdulla, M.A. and Ali, H.M. and Hadi, A.H.A. and Majid, N.A. (2013) Gastroprotection studies of Schiff Base Zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats. PLoS ONE, 8 (9). ISSN 1932-6203
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Golbabapour, S.
Gwaram, N.S.
Hassandarvish, P.
Hajrezaie, M.
Kamalidehghan, B.
Abdulla, M.A.
Ali, H.M.
Hadi, A.H.A.
Majid, N.A.
Gastroprotection studies of Schiff Base Zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats
description Background: The study was carried out to assess the gastroprotective effect of the zinc (II) complex against ethanol-induced acute hemorrhagic lesions in rats. Methodology/Principal Finding: The animals received their respective pre-treatments dissolved in tween 20 (5% v/v), orally. Ethanol (95% v/v) was orally administrated to induce superficial hemorrhagic mucosal lesions. Omeprazole (5.79061025 M/kg) was used as a reference medicine. The pre-treatment with the zinc (II) complex (2.18161025 and 4.36261025 M/kg) protected the gastric mucosa similar to the reference control. They significantly increased the activity levels of nitric oxide, catalase, superoxide dismutase, glutathione and prostaglandin E2, and decreased the level of malondialdehyde. The histology assessments confirmed the protection through remarkable reduction of mucosal lesions and increased the production of gastric mucosa. Immunohistochemistry and western blot analysis indicated that the complex might induced Hsp70 up-regulation and Bax down-regulation. The complex moderately increased the gastroprotectiveness in fine fettle. The acute toxicity approved the non-toxic characteristic of the complex(<87.24161025 M/kg). Conclusion/Significance: The gastroprotective effect of the zinc (II) complex was mainly through its antioxidant activity, enzymatic stimulation of prostaglandins E2, and up-regulation of Hsp70. The gastric wall mucus was also a remarkable protective mechanism.
format Article
author Golbabapour, S.
Gwaram, N.S.
Hassandarvish, P.
Hajrezaie, M.
Kamalidehghan, B.
Abdulla, M.A.
Ali, H.M.
Hadi, A.H.A.
Majid, N.A.
author_facet Golbabapour, S.
Gwaram, N.S.
Hassandarvish, P.
Hajrezaie, M.
Kamalidehghan, B.
Abdulla, M.A.
Ali, H.M.
Hadi, A.H.A.
Majid, N.A.
author_sort Golbabapour, S.
title Gastroprotection studies of Schiff Base Zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats
title_short Gastroprotection studies of Schiff Base Zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats
title_full Gastroprotection studies of Schiff Base Zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats
title_fullStr Gastroprotection studies of Schiff Base Zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats
title_full_unstemmed Gastroprotection studies of Schiff Base Zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats
title_sort gastroprotection studies of schiff base zinc (ii) derivative complex against acute superficial hemorrhagic mucosal lesions in rats
publisher Public Library of Science
publishDate 2013
url http://eprints.um.edu.my/10581/1/Gastroprotection_Studies_of_Schiff_Base_Zinc_%28II%29.pdf
http://eprints.um.edu.my/10581/
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score 13.214268