The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia
Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria. There is a scarcity in information about the magnitude of Plasmodium falciparum CQ resistance. This study aims to investigate the presence of single...
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2012
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my.um.eprints.105462014-06-13T01:21:50Z http://eprints.um.edu.my/10546/ The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia Atroosh, W.M. Al-Mekhlafi, H.M. Mahdy, M.A.K. Surin, J. Q Science (General) R Medicine (General) Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria. There is a scarcity in information about the magnitude of Plasmodium falciparum CQ resistance. This study aims to investigate the presence of single point mutations in the P. falciparum chloroquine-resistance transporter gene (pfcrt) at codons 76, 271, 326, 356 and 371 and in P. falciparum multi-drug resistance-1 gene (pfmdr1) at codons 86 and 1246, as molecular markers of CQ resistance BioMed Central 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10546/1/Detection_of_pfcrt_and_pfmdr1_point_mutations_as_molecular_markers_of_chloroquine_drug_resistance%2C_Pahang%2C_Malaysia.pdf Atroosh, W.M. and Al-Mekhlafi, H.M. and Mahdy, M.A.K. and Surin, J. (2012) The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia. Malaria Journal. |
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Q Science (General) R Medicine (General) Atroosh, W.M. Al-Mekhlafi, H.M. Mahdy, M.A.K. Surin, J. The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| description |
Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria. There is a scarcity in information about the magnitude of Plasmodium falciparum CQ resistance. This study aims to investigate the presence of single point mutations in the P. falciparum chloroquine-resistance transporter gene (pfcrt) at codons 76, 271, 326, 356 and 371 and in P. falciparum multi-drug resistance-1 gene (pfmdr1) at codons 86 and 1246, as molecular markers of CQ resistance |
| format |
Article |
| author |
Atroosh, W.M. Al-Mekhlafi, H.M. Mahdy, M.A.K. Surin, J. |
| author_facet |
Atroosh, W.M. Al-Mekhlafi, H.M. Mahdy, M.A.K. Surin, J. |
| author_sort |
Atroosh, W.M. |
| title |
The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_short |
The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_full |
The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_fullStr |
The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_full_unstemmed |
The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia |
| title_sort |
detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, pahang, malaysia |
| publisher |
BioMed Central |
| publishDate |
2012 |
| url |
http://eprints.um.edu.my/10546/1/Detection_of_pfcrt_and_pfmdr1_point_mutations_as_molecular_markers_of_chloroquine_drug_resistance%2C_Pahang%2C_Malaysia.pdf http://eprints.um.edu.my/10546/ |
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13.160551 |