Upregulation of insulin secretion and downregulation of pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats by Pseuduvaria monticola bark extract

• Main Authors: Taha, H., Arya, Aditya, Paydar, M., Looi, Chung Yeng, Wong, Won Fen, Murthy, C.R.V., Noordin, M.I., Ali, Hapipah Mohd, Mustafa, A.M., Hadi, A.H.A.
• Format: Article
• Language: English; English
• Published: Elsevier 2014
• Subjects: Q Science (General); QD Chemistry; R Medicine
• Online Access: http://eprints.um.edu.my/10514/1/Upregulation_of_insulin_secretion_and_downregulation.pdf; http://eprints.um.edu.my/10514/4/00011677_103500.pdf; http://eprints.um.edu.my/10514/; https://doi.org/10.1016/j.fct.2014.01.054

The current study aimed to ascertain the antidiabetic potential of Pseuduvaria monticola bark methanolic extract (PMm) using in vitro mechanistic study models. In particular, the study determined the effect of PMm on cellular viability, 2-NBDG glucose uptake, insulin secretion, and NF-jB translocat...