Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae)

• Main Authors: Awang, Khalijah, Mukhtar, Mat Ropi, Osman, Norfaizah, Hazni, Hazrina, Qureshi, Ahmad Kaleem, A. Hadi, A. Hamid, Zaima, Kazuma, Morita, Hiroshi, Litaudon, Marc
• Format: Article
• Language: English
• Published: MDPI 2012
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/10497/1/Neonaucline%2C_a_new_indole_alkaloid_from_the_leaves_of_Ochreinauclea_maingayii_%28Hook._f.%29_Ridsd._%28Rubiaceae%29.pdf; http://eprints.um.edu.my/10497/

A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1-3 after injection of each sample at 1 × 10-5 M.