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Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)

Two new dammarane triterpenoids, aglinone (1) and aglinin E (20S,24S-epoxy-25-hydroxy-1-en-dammarene) (2) along with three known compounds, 3-epiocotillol (3), aglinin A (4), and eichlerianic acid (5), were isolated from the bark of Aglaia smithii. The chemical structures of the new compound were el...

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Main Authors: Awang, Khalijah, Harneti, D., Tjokronegoro, R., Safari, A., Supratman, U., Loong, X.M., Mukhtar, M.R., Mohamad, K., Hayashi, H.
Format: Article
Language:English
Published: Elsevier 2012
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/10494/1/Cytotoxic_triterpenoids_from_the_bark_of_Aglaia_smithii_%28Meliaceae%29.pdf
http://eprints.um.edu.my/10494/
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spelling my.um.eprints.104942019-03-08T08:36:39Z http://eprints.um.edu.my/10494/ Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae) Awang, Khalijah Harneti, D. Tjokronegoro, R. Safari, A. Supratman, U. Loong, X.M. Mukhtar, M.R. Mohamad, K. Hayashi, H. QD Chemistry Two new dammarane triterpenoids, aglinone (1) and aglinin E (20S,24S-epoxy-25-hydroxy-1-en-dammarene) (2) along with three known compounds, 3-epiocotillol (3), aglinin A (4), and eichlerianic acid (5), were isolated from the bark of Aglaia smithii. The chemical structures of the new compound were elucidated on the basis of spectroscopic data interpretation. All the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1, 2, 4 and 5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 21, 42, 34, and 11 μg/mL, respectively. Elsevier 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10494/1/Cytotoxic_triterpenoids_from_the_bark_of_Aglaia_smithii_%28Meliaceae%29.pdf Awang, Khalijah and Harneti, D. and Tjokronegoro, R. and Safari, A. and Supratman, U. and Loong, X.M. and Mukhtar, M.R. and Mohamad, K. and Hayashi, H. (2012) Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae). Phytochemistry Letters, 5 (3). pp. 496-499. ISSN 1874-3900
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Awang, Khalijah
Harneti, D.
Tjokronegoro, R.
Safari, A.
Supratman, U.
Loong, X.M.
Mukhtar, M.R.
Mohamad, K.
Hayashi, H.
Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)
description Two new dammarane triterpenoids, aglinone (1) and aglinin E (20S,24S-epoxy-25-hydroxy-1-en-dammarene) (2) along with three known compounds, 3-epiocotillol (3), aglinin A (4), and eichlerianic acid (5), were isolated from the bark of Aglaia smithii. The chemical structures of the new compound were elucidated on the basis of spectroscopic data interpretation. All the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1, 2, 4 and 5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 21, 42, 34, and 11 μg/mL, respectively.
format Article
author Awang, Khalijah
Harneti, D.
Tjokronegoro, R.
Safari, A.
Supratman, U.
Loong, X.M.
Mukhtar, M.R.
Mohamad, K.
Hayashi, H.
author_facet Awang, Khalijah
Harneti, D.
Tjokronegoro, R.
Safari, A.
Supratman, U.
Loong, X.M.
Mukhtar, M.R.
Mohamad, K.
Hayashi, H.
author_sort Awang, Khalijah
title Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)
title_short Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)
title_full Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)
title_fullStr Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)
title_full_unstemmed Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)
title_sort cytotoxic triterpenoids from the bark of aglaia smithii (meliaceae)
publisher Elsevier
publishDate 2012
url http://eprints.um.edu.my/10494/1/Cytotoxic_triterpenoids_from_the_bark_of_Aglaia_smithii_%28Meliaceae%29.pdf
http://eprints.um.edu.my/10494/
_version_ 1643688813812252672
score 13.160551

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