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Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)

The new stigmastane steroid,3,4epoxy-(22R,25)-tetrahydrofuran-stigmast-5-en (1), along with two known triterpenoids (2–3) and two known steroids (4–5) were isolated from the stem bark of Aglaia eximia. The chemical structures of the new compound were elucidated on the basis of spectroscopic data. Al...

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Main Authors: Awang, Khalijah, Harneti, D., Supriadin, A., Ulfah, M., Safari, A., Supratman, U., Hayashi, H.
Format: Article
Language:English
Published: Elsevier 2014
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/10447/1/Cytotoxic_constituents_from_the_bark_of_Aglaia_eximia_%28Meliaceae%29.pdf
http://eprints.um.edu.my/10447/
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spelling my.um.eprints.104472019-03-01T09:23:58Z http://eprints.um.edu.my/10447/ Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae) Awang, Khalijah Harneti, D. Supriadin, A. Ulfah, M. Safari, A. Supratman, U. Hayashi, H. QD Chemistry The new stigmastane steroid,3,4epoxy-(22R,25)-tetrahydrofuran-stigmast-5-en (1), along with two known triterpenoids (2–3) and two known steroids (4–5) were isolated from the stem bark of Aglaia eximia. The chemical structures of the new compound were elucidated on the basis of spectroscopic data. All of the compounds were tested for their cytotoxic effects against P-388 murine leukemia cells.Compounds 1–5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 11.42, 4.26, 29.10, 45.96, and 52.09 mg/mL, respectively. Elsevier 2014 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10447/1/Cytotoxic_constituents_from_the_bark_of_Aglaia_eximia_%28Meliaceae%29.pdf Awang, Khalijah and Harneti, D. and Supriadin, A. and Ulfah, M. and Safari, A. and Supratman, U. and Hayashi, H. (2014) Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae). Phytochemistry Letters, 8. pp. 28-31. ISSN 1874-3900
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Awang, Khalijah
Harneti, D.
Supriadin, A.
Ulfah, M.
Safari, A.
Supratman, U.
Hayashi, H.
Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)
description The new stigmastane steroid,3,4epoxy-(22R,25)-tetrahydrofuran-stigmast-5-en (1), along with two known triterpenoids (2–3) and two known steroids (4–5) were isolated from the stem bark of Aglaia eximia. The chemical structures of the new compound were elucidated on the basis of spectroscopic data. All of the compounds were tested for their cytotoxic effects against P-388 murine leukemia cells.Compounds 1–5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 11.42, 4.26, 29.10, 45.96, and 52.09 mg/mL, respectively.
format Article
author Awang, Khalijah
Harneti, D.
Supriadin, A.
Ulfah, M.
Safari, A.
Supratman, U.
Hayashi, H.
author_facet Awang, Khalijah
Harneti, D.
Supriadin, A.
Ulfah, M.
Safari, A.
Supratman, U.
Hayashi, H.
author_sort Awang, Khalijah
title Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)
title_short Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)
title_full Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)
title_fullStr Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)
title_full_unstemmed Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)
title_sort cytotoxic constituents from the bark of aglaia eximia (meliaceae)
publisher Elsevier
publishDate 2014
url http://eprints.um.edu.my/10447/1/Cytotoxic_constituents_from_the_bark_of_Aglaia_eximia_%28Meliaceae%29.pdf
http://eprints.um.edu.my/10447/
_version_ 1643688801235632128
score 13.160551

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