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Outbreak of typhoid fever in non-endemic area: comparison of three molecular typing methods

An outbreak of typhoid fever in Zurich, Switzerland, which involved seven customers and three employees of a city mall restaurant, was investigated by comparing three molecular typing methods: pulsed-field gel electrophoresis (PFGE), ribosomal RNA gene restriction patterns (ribotyping), and random...

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Bibliographic Details
Main Authors: Gruner, E., Flepp, M., Gabathuler, U., Thong, Kwai Lin, Altwegg, M.
Format: Article
Language:English
Published: Elsevier 1997
Subjects:
QR Microbiology
Online Access:http://eprints.um.edu.my/10420/1/Gruner_et_al.%2C_1997.pdf
http://eprints.um.edu.my/10420/
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Summary:An outbreak of typhoid fever in Zurich, Switzerland, which involved seven customers and three employees of a city mall restaurant, was investigated by comparing three molecular typing methods: pulsed-field gel electrophoresis (PFGE), ribosomal RNA gene restriction patterns (ribotyping), and random amplified polymorphic DNA (RAPD). Both PFGE and ribotyping identified two molecular patterns among the outbreak-related isolates which differed in one band: these isolates were considered clonally related and differed clearly from other unrelated S. typhi strains. RAPD could not distinguish among outbreak isolates and control strains.

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