Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial
Background & aims: Probiotics is an emerging therapeutic agent which may alleviate the symptoms of constipation. We evaluated the effectiveness of microbial cell preparation (Hexbio®) containing fructooligosaccharide,Bifidobacterium and Lactobacillus in improving stool frequency and symptoms of...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10195/1/Efficacy_of_microbial_cell_preparation_in_improving_chronic.pdf http://eprints.um.edu.my/10195/ |
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| Summary: | Background & aims: Probiotics is an emerging therapeutic agent which may alleviate the symptoms of constipation. We evaluated the effectiveness of microbial cell preparation (Hexbio®) containing fructooligosaccharide,Bifidobacterium and Lactobacillus in improving stool frequency and symptoms of chronic constipation.
Methods: A total of 120 constipated adults diagnosed using Rome III criteria were randomized and given
either microbial cell preparation or placebo to be consumed twice daily. Follow-up was done after a 7-day intervention based on a questionnaire which includes an assessment of symptom profile and a stool diary.
Results: During the intervention period, the stool frequency was higher (p = 0.001) in the treatment group. Subjects experienced less straining (p = 0.001) and sensation of incomplete evacuation (p < 0.001), as well as improved stool consistency (p < 0.001) compared to the placebo group. While a higher proportion of subjects in the treatment group had a reduction in anorectal blockage sensation and having to defecate by manual maneuvers, the differences were not statistically significant. |
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