Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)

• Main Author: Leong, K.H.
• Format: Article
• Language: English
• Published: Elsevier 2012
• Subjects: Q Science (General); QD Chemistry; QH301 Biology; QK Botany; R Medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer); RM Therapeutics. Pharmacology; RS Pharmacy and materia medica; RV Botanic, Thomsonian, and eclectic medicine
• Online Access: http://eprints.um.edu.my/10001/1/1Triterpenes_and_steroids_from_the_leaves_of_Aglaia_exima_%28Meliaceae%29.pdf; http://eprints.um.edu.my/10001/; http://www.sciencedirect.com/science/article/pii/S0367326X12002808

A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM).