Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi

AIM: This study sets to investigate the effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose (HPMC) solution. METHOD: The HPMC solution, with or without the incorporation of additives, was subjected to viscosity test using a rotatory viscometer and at a solut...

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Main Author: Zabidi, Azreen Suzyliana
Format: Thesis
Language:English
Published: 2005
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Online Access:https://ir.uitm.edu.my/id/eprint/98634/1/98634.PDF
https://ir.uitm.edu.my/id/eprint/98634/
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spelling my.uitm.ir.986342024-07-22T08:19:55Z https://ir.uitm.edu.my/id/eprint/98634/ Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi Zabidi, Azreen Suzyliana RM Therapeutics. Pharmacology RS Pharmacy and materia medica AIM: This study sets to investigate the effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose (HPMC) solution. METHOD: The HPMC solution, with or without the incorporation of additives, was subjected to viscosity test using a rotatory viscometer and at a solution temperatures of 30 to 60°C unless otherwise stated. The additives used were trisodium citrate, citric acid, triethylcitrate and triacetin. RESULT: The viscosity of aqueous HPMC solutions was reduced when appropriate amounts of trisodium citrate, citric acid, triethylcitrate and triacetin were added. Using 1% w/w HPMC solution, triethylcitrate demonstrated the best viscosity lowering effect when solution temperature of 30 to 50°C were concerned while trisodium citrate exhibited a marked viscosity lowering property at 60°C. Using 1.5% w/w HPMC solution, smaller additive such as citric acid gave rise to the most prominent viscosity lowering property. CONCLUSION: Trisodium citrate, citric acid, triethylcitrate and triacetin exhibited viscosity lowering property in HPMC solution. 2005 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/98634/1/98634.PDF Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi. (2005) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Zabidi, Azreen Suzyliana
Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
description AIM: This study sets to investigate the effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose (HPMC) solution. METHOD: The HPMC solution, with or without the incorporation of additives, was subjected to viscosity test using a rotatory viscometer and at a solution temperatures of 30 to 60°C unless otherwise stated. The additives used were trisodium citrate, citric acid, triethylcitrate and triacetin. RESULT: The viscosity of aqueous HPMC solutions was reduced when appropriate amounts of trisodium citrate, citric acid, triethylcitrate and triacetin were added. Using 1% w/w HPMC solution, triethylcitrate demonstrated the best viscosity lowering effect when solution temperature of 30 to 50°C were concerned while trisodium citrate exhibited a marked viscosity lowering property at 60°C. Using 1.5% w/w HPMC solution, smaller additive such as citric acid gave rise to the most prominent viscosity lowering property. CONCLUSION: Trisodium citrate, citric acid, triethylcitrate and triacetin exhibited viscosity lowering property in HPMC solution.
format Thesis
author Zabidi, Azreen Suzyliana
author_facet Zabidi, Azreen Suzyliana
author_sort Zabidi, Azreen Suzyliana
title Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_short Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_full Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_fullStr Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_full_unstemmed Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_sort effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / azreen suzyliana zabidi
publishDate 2005
url https://ir.uitm.edu.my/id/eprint/98634/1/98634.PDF
https://ir.uitm.edu.my/id/eprint/98634/
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score 13.188404