Impurity profiling of a drug substances / Nur Salima Shamsudin
Carbimazole is an antithyroid drug and is used in treating hyperthyroidism. Carbimazole itself is inactive, but it is rapidly converted to methimazole. This thesis described a thin layer chromatography (TLC) method and a validated high performance liquid chromatography (HPLC) detection method to ide...
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2005
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my.uitm.ir.986302024-07-22T08:44:10Z https://ir.uitm.edu.my/id/eprint/98630/ Impurity profiling of a drug substances / Nur Salima Shamsudin Shamsudin, Nur Salima RM Therapeutics. Pharmacology RS Pharmacy and materia medica Carbimazole is an antithyroid drug and is used in treating hyperthyroidism. Carbimazole itself is inactive, but it is rapidly converted to methimazole. This thesis described a thin layer chromatography (TLC) method and a validated high performance liquid chromatography (HPLC) detection method to identify and also to determine the amount of impurity present in carbimazole sample. Solvents used in TLC method were dichloromethane, chloroform and acetone as mobile phase. The TLC plate used was TLC aluminium sheets, 20 x 20 cm, Silica Gel 60 F254. The HPLC was equipped with column ZORBAX 300SB-CI8, 5 pm, dimension 4.6 x 150 mm, manual injector with 20pl loop and a UV detector. The separation was achieved using acetonitrile and water as mobile phase at a flow rate of 1.2 ml/min.The impurity and amount of carbimazole in carbimazole tablet were found. The limit of detection on TLC method was 1 mg/ml while for HPLC was 0.025 pg/ml. A suitable method was developed to identify and quantitate carbimazole compound and its impurity in carbimazole tablet. 2005 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/98630/1/98630.PDF Impurity profiling of a drug substances / Nur Salima Shamsudin. (2005) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam). |
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RM Therapeutics. Pharmacology RS Pharmacy and materia medica Shamsudin, Nur Salima Impurity profiling of a drug substances / Nur Salima Shamsudin |
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Carbimazole is an antithyroid drug and is used in treating hyperthyroidism. Carbimazole itself is inactive, but it is rapidly converted to methimazole. This thesis described a thin layer chromatography (TLC) method and a validated high performance liquid chromatography (HPLC) detection method to identify and also to determine the amount of impurity present in carbimazole sample. Solvents used in TLC method were dichloromethane, chloroform and acetone as mobile phase. The TLC plate used was TLC aluminium sheets, 20 x 20 cm, Silica Gel 60 F254. The HPLC was equipped with column ZORBAX 300SB-CI8, 5 pm, dimension 4.6 x 150 mm, manual injector with 20pl loop and a UV detector. The separation was achieved using acetonitrile and water as mobile phase at a flow rate of 1.2 ml/min.The impurity and amount of carbimazole in carbimazole tablet were found. The limit of detection on TLC method was 1 mg/ml while for HPLC was 0.025 pg/ml. A suitable method was developed to identify and quantitate carbimazole compound and its impurity in carbimazole tablet. |
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Thesis |
author |
Shamsudin, Nur Salima |
author_facet |
Shamsudin, Nur Salima |
author_sort |
Shamsudin, Nur Salima |
title |
Impurity profiling of a drug substances / Nur Salima Shamsudin |
title_short |
Impurity profiling of a drug substances / Nur Salima Shamsudin |
title_full |
Impurity profiling of a drug substances / Nur Salima Shamsudin |
title_fullStr |
Impurity profiling of a drug substances / Nur Salima Shamsudin |
title_full_unstemmed |
Impurity profiling of a drug substances / Nur Salima Shamsudin |
title_sort |
impurity profiling of a drug substances / nur salima shamsudin |
publishDate |
2005 |
url |
https://ir.uitm.edu.my/id/eprint/98630/1/98630.PDF https://ir.uitm.edu.my/id/eprint/98630/ |
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