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Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan

Theophylline is a therapy for respiratory diseases which has limited use due to its rapid absorption and becomes inactive metabolite as methyluric acid when administered in the body system. These limitations can be reduced by complexation with inclusion of the beta cyclodextrin. The complex was prep...

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Main Authors: Mokhtar, Marina, Adnan, Rohana
Format: Article
Published: Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) 2012
Online Access:http://ir.uitm.edu.my/id/eprint/8863/
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spelling my.uitm.ir.88632017-09-19T09:12:55Z http://ir.uitm.edu.my/id/eprint/8863/ Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan Mokhtar, Marina Adnan, Rohana Theophylline is a therapy for respiratory diseases which has limited use due to its rapid absorption and becomes inactive metabolite as methyluric acid when administered in the body system. These limitations can be reduced by complexation with inclusion of the beta cyclodextrin. The complex was prepared by kneading, slow evaporation and freeze drying methods. The structure of the complex was determined by FT-IR, DSC and 1H NMR. The molecular modeling study indicated theophylline lies exactly in the cavity of β-CD with hydrogen bonding. Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) 2012 Article NonPeerReviewed Mokhtar, Marina and Adnan, Rohana (2012) Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan. Esteem Academic Journal, 8 (2). pp. 50-63. ISSN 1675-7939
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
description Theophylline is a therapy for respiratory diseases which has limited use due to its rapid absorption and becomes inactive metabolite as methyluric acid when administered in the body system. These limitations can be reduced by complexation with inclusion of the beta cyclodextrin. The complex was prepared by kneading, slow evaporation and freeze drying methods. The structure of the complex was determined by FT-IR, DSC and 1H NMR. The molecular modeling study indicated theophylline lies exactly in the cavity of β-CD with hydrogen bonding.
format Article
author Mokhtar, Marina
Adnan, Rohana
spellingShingle Mokhtar, Marina
Adnan, Rohana
Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan
author_facet Mokhtar, Marina
Adnan, Rohana
author_sort Mokhtar, Marina
title Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan
title_short Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan
title_full Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan
title_fullStr Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan
title_full_unstemmed Preparation method and characterization of inclusion complex of Theophylline/Beta / Marina Mokhtar and Rohana Adnan
title_sort preparation method and characterization of inclusion complex of theophylline/beta / marina mokhtar and rohana adnan
publisher Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA)
publishDate 2012
url http://ir.uitm.edu.my/id/eprint/8863/
_version_ 1685648255211274240
score 13.160551

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