PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi

• Main Author: Azmi, Nor Aniza
• Format: Thesis
• Language: English
• Published: 2018
• Subjects: RC Internal Medicine; Research. Experimentation
• Online Access: https://ir.uitm.edu.my/id/eprint/82867/1/82867.pdf; https://ir.uitm.edu.my/id/eprint/82867/

This study involved assessment of clinician’s views on practicality, clinical efficacy and cost –effectiveness of PET-CT in oesophageal cancer management and decision making model-based economic evaluation to investigate the relative cost-effectiveness of PET/CT in oesophageal cancer management staging based on review of publications and retrospective data. Total of 73 clinicians included in the survey. Retrospective analysis of patient data from 2001-2008 taken from Royal Liverpool &Broadgreen University Hospital Trust (RLBUHT) medical records and North West Cancer Intelligence Services (NWCIS) database for the same period. A decision tree was developed using TREEAGE software. The relevant data on accuracy, sensitivity and specificity of each diagnostic test were linked in the model, to cost and the primary outcome measure, cost per quality-adjusted life-year (QALY). The model estimated the mean cost associated with each diagnostic procedure and assumed that patients entering the model were aged 35-75 years. The results of the cost-effectiveness analysis are presented in terms of the incremental cost-effectiveness ratios (ICERs).PET compared with conventional work-up results for ICER for the strategy estimated at £28,460 per QALY; PET/CT compared with PET for ICER was £ 32,590 per QALY; and the ICER for PET/CT combined with conventional work-up versus PET/CT was £ 44,118. The package become more expensive with each additional diagnostic test added to PET and the more effective in terms of QALYs gained. The conventional work-up is the preferred options as probabilistic sensitivity analysis shows at a willingness-to-pay (WTP) threshold of £ 20,000 per QALY.