Development of a thermostabilised PCR-based detection kit for pathogenic familial hypercholesterolaemia variants in Malaysia / Norhidayah Rosman

• Main Author: Rosman, Norhidayah
• Format: Thesis
• Language: English
• Published: 2022
• Subjects: Diseases of the circulatory (Cardiovascular) system; Individual drugs and other agents
• Online Access: https://ir.uitm.edu.my/id/eprint/77969/1/77969.pdf; https://ir.uitm.edu.my/id/eprint/77969/

Familial hypercholesterolaemia (FH) is an inherited disease that causes an elevation of plasma low-density lipoprotein cholesterol (LDL-C) level, leading to increased risk of premature coronary artery disease. Next-generation sequencing (NGS) is currently used to detect FH variants molecularly among...