Development of diagnostic kit for human oral squamous cell carcinoma / Kazi Ahsan Jamil … [et al.]

• Main Authors: Jamil, Kazi Ahsan, Sulaiman, Fatimah Suriati, Khor, Goot Heah, Mohd Zain, Rosnah
• Format: Book Section
• Language: English
• Published: Research Innovation Business Unit 2014
• Subjects: Medical technology; RK Dentistry; Oral and dental anatomy and physiology
• Online Access: https://ir.uitm.edu.my/id/eprint/73341/1/73341.pdf; https://ir.uitm.edu.my/id/eprint/73341/; http://www.iidex.com.my

p53 gene mutations observed at about 50 to 60 % in oral squamous cell carcinoma (OSCC). Problem Statement: The common mutation sites of p53 gene are still in controversy. Different techniques give differ results and even using same technique the results are different. Recently, Multiplex Ligation-Probe Amplification (MLPA) has been shown to be reliable and efficient technique for the detection of mutation. This method was consistent with cytogenetic and FISH (Fluorescence in situ hybridization) methods.