Docking of mouse p-glycoprotein (ABCB1a/MDR3) with Rhodamine B and Vinblastine / Hazureen Mohd Halimi

• Main Author: Mohd Halimi, Hazureen
• Format: Thesis
• Language: English
• Published: 2012
• Subjects: Peptides. Amino acid sequence; Data processing. Bioinformatics
• Online Access: https://ir.uitm.edu.my/id/eprint/66678/1/66678.pdf; https://ir.uitm.edu.my/id/eprint/66678/

P-glycoprotein (Pgp) is an ATP-dependent transport protein that is selectively expressed at entry points of xenobiotics. It acts as an efflux pump that prevents xenobiotics from entering sensitive organs. Pgp also plays a key role in the absorption and blood-brain barrier penetration of many drugs....