Predicting AAK1/GAK dual-target inhibitor against SARS-CoV-2 viral entry into host cells: an in silico approach / Xavier Chee Wezen ...[et.al.]

• Main Authors: Wezen, Xavier Chee, Clement, Sim Jun Wen, Yung Ping, Lilian Siaw, Yeong, Kah Ho, Qing, Kong Hao, Ha, Christopher, San, Hwang Siaw
• Format: Article
• Language: English
• Published: UiTM Press 2021
• Subjects: Q Science (General); QH Natural history - Biology; Biology; R Medicine (General)
• Online Access: https://ir.uitm.edu.my/id/eprint/63445/1/63445.pdf; https://ir.uitm.edu.my/id/eprint/63445/; https://jsst.uitm.edu.my/index.php/jsst/issue/view/1

Clathrin-mediated endocytosis (CME) is a normal biological process where cellular contents are transported into the cells.However, this process is often hijacked by different viruses to enter host cells and cause infections. Recently, two proteins that regulate CME – AAK1 and GAK – have been propose...