Total synthesis and biological studies of a new anti-proteasome drug, lactacystin and its derivatives / Ahmad Sazali Hamzah and Zurina Shaameri

• Main Authors: Hamzah, Ahmad Sazali, Shaameri, Zurina
• Format: Research Reports
• Language: English
• Published: 2005
• Subjects: Study and teaching. Research; Biological laboratories and stations
• Online Access: https://ir.uitm.edu.my/id/eprint/49453/1/49453.pdf; https://ir.uitm.edu.my/id/eprint/49453/

Lactacystin is the first non-protein metabolite isolated from Streptomyces specie by Omura in 1991. It mimics the nerve growth factor because it inhibits cell growth and induces neurite outgrowth. Since nerve growth factor is essential for the survival and function of nerve cells or neurons, lactacy...