Bioactive compounds from Apama Corymbosa / Siti Zaiton Mat So'ad and Nik Idris Yusoff
Apama corymbosa (Grifl)Willd. (Syn. Thottea corymbosa Griff) known as akar julong bukit, akar surai (Malay) is a shrub found in the forests of Malaysia and Sumatra. Preliminary studies on Apama tomentosa showed that the plant contained Aristolochic acid, Aristololactam, steroid and fatty acids. Aris...
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my.uitm.ir.378462022-01-11T08:21:54Z https://ir.uitm.edu.my/id/eprint/37846/ Bioactive compounds from Apama Corymbosa / Siti Zaiton Mat So'ad and Nik Idris Yusoff Mat So'ad, Siti Zaiton Yusoff, Nik Idris Organic chemistry Biochemistry SD Forestry Apama corymbosa (Grifl)Willd. (Syn. Thottea corymbosa Griff) known as akar julong bukit, akar surai (Malay) is a shrub found in the forests of Malaysia and Sumatra. Preliminary studies on Apama tomentosa showed that the plant contained Aristolochic acid, Aristololactam, steroid and fatty acids. Aristolochic acid has been reported to increase phagocytosis of leucocytes and exhibit tumour inhibitory activity. The roots of T.corymbosa collected from Ayer Hitam Forest Reserve, Puchong were extracted by conventional method using petroleum ether,chloroform and methanol. In this paper we will discuss the isolation and purification of the toxic crude from chloroform extract. Brine Shrimp Lethallity Bioassay gave LCso-200 ppm. Separation and isolation of the components were carried out using chromatographic methods(CC,PTLC,FCC,SPE). Structural identifications were achieved by spectroscopic methods i.e. GC-MS,IR,UV, 'H- and 13C-NMR. As a result three major known compounds isolated were identified as Ariskanin-A, Ariskanin-D and Cepharadione-A. Universiti Teknologi MARA Cawangan Pahang 2002-01 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/37846/1/37846.PDF ID37846 Mat So'ad, Siti Zaiton and Yusoff, Nik Idris (2002) Bioactive compounds from Apama Corymbosa / Siti Zaiton Mat So'ad and Nik Idris Yusoff. Gading Jurnal Akademik, 1,2 (7). pp. 76-82. ISSN 0128-5599 |
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Organic chemistry Biochemistry SD Forestry Mat So'ad, Siti Zaiton Yusoff, Nik Idris Bioactive compounds from Apama Corymbosa / Siti Zaiton Mat So'ad and Nik Idris Yusoff |
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Apama corymbosa (Grifl)Willd. (Syn. Thottea corymbosa Griff) known as akar julong bukit, akar surai (Malay) is a shrub found in the forests of Malaysia and Sumatra. Preliminary studies on Apama tomentosa showed that the plant contained Aristolochic acid, Aristololactam, steroid and fatty acids. Aristolochic acid has been reported to increase phagocytosis of leucocytes and exhibit tumour inhibitory activity. The roots of T.corymbosa collected from Ayer Hitam Forest Reserve, Puchong were extracted by conventional method using petroleum ether,chloroform and methanol. In this paper we will discuss the isolation and purification of the toxic crude from chloroform extract. Brine Shrimp Lethallity Bioassay gave LCso-200 ppm. Separation and isolation of the components were carried out using chromatographic methods(CC,PTLC,FCC,SPE). Structural identifications were achieved by spectroscopic methods i.e. GC-MS,IR,UV, 'H- and 13C-NMR. As a result three major known compounds isolated were identified as Ariskanin-A, Ariskanin-D and Cepharadione-A. |
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Article |
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Mat So'ad, Siti Zaiton Yusoff, Nik Idris |
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Mat So'ad, Siti Zaiton Yusoff, Nik Idris |
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Mat So'ad, Siti Zaiton |
title |
Bioactive compounds from Apama Corymbosa / Siti Zaiton Mat So'ad and Nik Idris Yusoff |
title_short |
Bioactive compounds from Apama Corymbosa / Siti Zaiton Mat So'ad and Nik Idris Yusoff |
title_full |
Bioactive compounds from Apama Corymbosa / Siti Zaiton Mat So'ad and Nik Idris Yusoff |
title_fullStr |
Bioactive compounds from Apama Corymbosa / Siti Zaiton Mat So'ad and Nik Idris Yusoff |
title_full_unstemmed |
Bioactive compounds from Apama Corymbosa / Siti Zaiton Mat So'ad and Nik Idris Yusoff |
title_sort |
bioactive compounds from apama corymbosa / siti zaiton mat so'ad and nik idris yusoff |
publisher |
Universiti Teknologi MARA Cawangan Pahang |
publishDate |
2002 |
url |
https://ir.uitm.edu.my/id/eprint/37846/1/37846.PDF https://ir.uitm.edu.my/id/eprint/37846/ |
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