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Molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / Maimunah Mustakim

The development of atherosclerotic plaques is a multistep process involving changes in blood lipid composition, dysfunction of the endothelium, and infiltration of inflammatory cells. Cellular and molecular studies revealed enhanced expressions of several genes in development of atherosclerosis. Thi...

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Main Author: Mustakim, Maimunah
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2014
Subjects:
Malaysia
Online Access:http://ir.uitm.edu.my/id/eprint/19616/1/ABS_MAIMUNAH%20MUSTAKIM%20TDRA%20VOL%206%20IGS_14.pdf
http://ir.uitm.edu.my/id/eprint/19616/
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spelling my.uitm.ir.196162018-06-07T02:43:42Z http://ir.uitm.edu.my/id/eprint/19616/ Molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / Maimunah Mustakim Mustakim, Maimunah Malaysia The development of atherosclerotic plaques is a multistep process involving changes in blood lipid composition, dysfunction of the endothelium, and infiltration of inflammatory cells. Cellular and molecular studies revealed enhanced expressions of several genes in development of atherosclerosis. This thesis aimed to investigate whether changed expressions of endothelial surface genes (VCAM, ICAM, and selectins), MCP-1, MMPs, and tissue inhibitor of MMPs (TIMPs) are associated with the underlying changes of the endothelium and subendothelial space in the development of atherosclerosis. In addition, the present study also determined whether any novel differentially expressed gene (DEG) is associated with atherogenesis. Rabbits were fed with 1 % cholesterol to induce atherosclerosis. Blood serum was collected for lipid profile analysis. Aorta tissues were used to study changes in morphology, ultrastructure, and gene expressions. Institute of Graduate Studies, UiTM 2014 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19616/1/ABS_MAIMUNAH%20MUSTAKIM%20TDRA%20VOL%206%20IGS_14.pdf Mustakim, Maimunah (2014) Molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / Maimunah Mustakim. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 6 (6). Institute of Graduate Studies, UiTM, Shah Alam.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Malaysia
spellingShingle Malaysia
Mustakim, Maimunah
Molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / Maimunah Mustakim
description The development of atherosclerotic plaques is a multistep process involving changes in blood lipid composition, dysfunction of the endothelium, and infiltration of inflammatory cells. Cellular and molecular studies revealed enhanced expressions of several genes in development of atherosclerosis. This thesis aimed to investigate whether changed expressions of endothelial surface genes (VCAM, ICAM, and selectins), MCP-1, MMPs, and tissue inhibitor of MMPs (TIMPs) are associated with the underlying changes of the endothelium and subendothelial space in the development of atherosclerosis. In addition, the present study also determined whether any novel differentially expressed gene (DEG) is associated with atherogenesis. Rabbits were fed with 1 % cholesterol to induce atherosclerosis. Blood serum was collected for lipid profile analysis. Aorta tissues were used to study changes in morphology, ultrastructure, and gene expressions.
format Book Section
author Mustakim, Maimunah
author_facet Mustakim, Maimunah
author_sort Mustakim, Maimunah
title Molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / Maimunah Mustakim
title_short Molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / Maimunah Mustakim
title_full Molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / Maimunah Mustakim
title_fullStr Molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / Maimunah Mustakim
title_full_unstemmed Molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / Maimunah Mustakim
title_sort molecular events associated with underlying changes of the vascular endothelium and subendothelial space during atherogenesis in an animal model / maimunah mustakim
publisher Institute of Graduate Studies, UiTM
publishDate 2014
url http://ir.uitm.edu.my/id/eprint/19616/1/ABS_MAIMUNAH%20MUSTAKIM%20TDRA%20VOL%206%20IGS_14.pdf
http://ir.uitm.edu.my/id/eprint/19616/
_version_ 1685649237151318016
score 13.214268

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