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Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad

There are three documented polymorphisms in exon 2 of Human Glucocorticoid Receptor gene (NR3Cl). These include ER22/23EK, N363S and Bell. ER22/23EK induces glucocorticoid resistance while N363S and Bell cause hypersensitivity towards glucocorticoids. A probable novel SNP (C408 l 4T) has been detect...

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Main Author: Ahmad, Afiqah
Format: Thesis
Language:English
Published: 2014
Subjects:
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/111123/1/111123.PDF
https://ir.uitm.edu.my/id/eprint/111123/
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spelling my.uitm.ir.1111232025-03-04T23:10:25Z https://ir.uitm.edu.my/id/eprint/111123/ Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad Ahmad, Afiqah Pharmaceutical chemistry There are three documented polymorphisms in exon 2 of Human Glucocorticoid Receptor gene (NR3Cl). These include ER22/23EK, N363S and Bell. ER22/23EK induces glucocorticoid resistance while N363S and Bell cause hypersensitivity towards glucocorticoids. A probable novel SNP (C408 l 4T) has been detected in a sample where it produces a synonymous mutation with no change in the amino acid. AS-PCR can be done in the future to screen larger group of samples to validate the presence of this SNP. 2014 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/111123/1/111123.PDF Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad. (2014) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical chemistry
spellingShingle Pharmaceutical chemistry
Ahmad, Afiqah
Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad
description There are three documented polymorphisms in exon 2 of Human Glucocorticoid Receptor gene (NR3Cl). These include ER22/23EK, N363S and Bell. ER22/23EK induces glucocorticoid resistance while N363S and Bell cause hypersensitivity towards glucocorticoids. A probable novel SNP (C408 l 4T) has been detected in a sample where it produces a synonymous mutation with no change in the amino acid. AS-PCR can be done in the future to screen larger group of samples to validate the presence of this SNP.
format Thesis
author Ahmad, Afiqah
author_facet Ahmad, Afiqah
author_sort Ahmad, Afiqah
title Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad
title_short Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad
title_full Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad
title_fullStr Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad
title_full_unstemmed Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad
title_sort detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (nr3c1) using polymerase chain reaction (pcr) / afiqah ahmad
publishDate 2014
url https://ir.uitm.edu.my/id/eprint/111123/1/111123.PDF
https://ir.uitm.edu.my/id/eprint/111123/
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score 13.244413

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