TPGS-1000 based palm oil nanoemulsion: feasibility studies, system design, emulsification and characterisation / Fazlina Mohamed

• Main Author: Mohamed, Fazlina
• Format: Thesis
• Language: English
• Published: 2014
• Subjects: Pharmacopoeias
• Online Access: https://ir.uitm.edu.my/id/eprint/111081/1/111081.PDF; https://ir.uitm.edu.my/id/eprint/111081/

The present study proposed D-a-tocopheryl polyethylene glycol 1000 succinate (TPGS-1000) as an emulsifying agent in optimizing a palm oil emulsion due to its various beneficial properties which lead to the preparation of an emulsion of high stability. TPGS 1000 is a water soluble derivatives of natural vitamin E which produced from the esterification of vitamin E succinate with polyethylene glycol. It is served as the excipient for overcoming multidrug resistance (MDR) and become an inhibitor of P-glycoprotein (P-gp) to increase an oral bioavailability of anticancer drugs. TPGS can act as anticancer agent, thus it can induce apoptosis and gain synergistic effect with other anticancer drugs. It is a non-ionic surfactant, having high HLB value of 13.2 and lower critical micelle concentration of 0.02% w/w, thus it is used in many areas such as drug delivery, solubility enhancement, wetting, emulsification as well as detergency. Palm oil is extracted from the mesocarp of the fruit of an oil palm species called Elaeis guineensis and it is widely used as cooking oil. In this study, palm oil which is a vegetable oil is used as an oil phase in the preparation of an emulsion, thus the study provide a promising approach to deliver an effective formulation containing palm oil to the right site of action. The TPGS- 1000 based palm oil emulsion are studied for their stability in terms of physical appearance and the droplet size, zeta potential, dynamic mobility and debye length are measured and recorded during the storage period of the formulation.