Preservative-free sterile eye drops container design / Hayatun Nufus Othman

• Main Author: Othman, Hayatun Nufus
• Format: Thesis
• Language: English
• Published: 2013
• Subjects: Pharmacopoeias
• Online Access: https://ir.uitm.edu.my/id/eprint/110243/1/110243.PDF; https://ir.uitm.edu.my/id/eprint/110243/

The aim of this study was to design eye drop container where dispensing of medication can be affected without introducing microbial load into the unused content. The preservative - free sterile eye drops container was prepared by designing the types of preservative - free sterile eye drops container that incorporated with valve, flexible nozzle, and small hole which located at the dispensing tip with the open and close cap. The mechanism flow of preservative - free sterile eye drops container was shown and subjected by using the 3 ml latex free syringe attached with the I ml of small needle syringe implemented. The bacterial detection had been investigated by spreading the 1 ml of sterile solution that may kept inside the syringe over the entire nutrient agar surface. The microbial colonies images revealed that the multiple application container with flexible nozzle used for air expulsion to remove residual liquid reduce the microbial contamination. The preservative - free sterile eye drops container with flexible nozzle which resulted in reduce the bacterial contamination than current eye drops.