Chemical derivatization of prednisone / Marliana Mohd Jajuli

• Main Author: Mohd Jajuli, Marliana
• Format: Thesis
• Language: English
• Published: 2013
• Subjects: Pharmacopoeias; Pharmaceutical chemistry
• Online Access: https://ir.uitm.edu.my/id/eprint/109610/1/109610.PDF; https://ir.uitm.edu.my/id/eprint/109610/

Prednisone gives many benefits to human in medical field because of its anti­ inflammatory effect. These favorable benefits lead to the development of many synthetic compounds with much greater anti-inflammatory activity than the natural hormones. Therefore, this research was done to produce other derivatives of prednisone, by synthesizing it using chemicals like acetic anhydride, benzoyl chloride, 4-bromobenzoyl chloride and 4-(dimethylarnino)benzoyl chloride, by using the most optimum time and temperature for its derivatization. Thin Layer Chromatography was used to monitor the reaction and purity of product. This study showed that under optimum temperature and time, pure derivative for prednisone can be obtained.