Molecular docking study of quassinoids derivatives and mouse P-glycoprotein / Farahen Abd Hadi
P-glycoprotein is a multidrug resistance protein that caused the failure of chemotherapeutic treatments due to the protein overexpression in cancer cells. Quassinoid is a natural compound that exhibits an antileukernic activity which has potential to treat cancer disease. In this study, quassinoids...
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| Format: | Thesis |
| Language: | English |
| Published: |
2013
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| Online Access: | https://ir.uitm.edu.my/id/eprint/109598/1/109598.PDF https://ir.uitm.edu.my/id/eprint/109598/ |
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| Summary: | P-glycoprotein is a multidrug resistance protein that caused the failure of chemotherapeutic treatments due to the protein overexpression in cancer cells. Quassinoid is a natural compound that exhibits an antileukernic activity which has potential to treat cancer disease. In this study, quassinoids derivatives are predicted to have potential interaction with the p-glycoprotein. The results from Autodock Vina presents the finding of interaction between quassinoids derivatives-P glycoprotein complexes. The results obtained show the quassinoids derivatives bind to amino acid residues GLN 986 of P-glycoprotein This study shows the potential interactions of quassinoids derivatives with P-glycoprotein. |
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