Paclitaxel loaded and surface coated poly methacrylic acid-peg-chitosan based nanoparticles for breast cancer delivery / Mohd Shafiq Mat Tahir

• Main Author: Mat Tahir, Mohd Shafiq
• Format: Thesis
• Language: English
• Published: 2013
• Subjects: Cancer
• Online Access: https://ir.uitm.edu.my/id/eprint/109578/1/109578.PDF; https://ir.uitm.edu.my/id/eprint/109578/

Polymeric nanoparticles have shown tremendous promise for targeted delivery of various chemotherapeutic agents. The aim of present work was to develop and characterize paclitaxel incorporated Poly MAAc based nanoparticles for breast cancer delivery. The polymer nanoparticles were developed by aqueous dispersion polymerization method. The physicochemical properties of the nanoparticles were evaluated by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetric analysis {TGA). Surface charge and morphology of the polymer nanoparticles were evaluated by Zeta potential, scanning electron microscopy (SEM) and Transmission electron microscopy (TEM). The nanoparticles had spherical shape under TEM with sizes smaller than 50 nm. The zeta potential analysis showed that all nanoparticles (blank and paclitaxel loaded) bearing negative charges on their surface and no aggregation was observed in the nanoparticles. The higher zeta potential value of polymer nanoparticles showed more stability of nanoparticles in emulsion. The DSC studies on nanoparticles showed emergence of glass transition which probably associated with miscible nature of polymer and paclitaxel. TGA study showed some improvement in thermal stability after incorporation with paclitaxel. The results demonstrated that paclitaxel loaded PMAAc nanoparticles are a promising candidate for antitumor drug delivery.